ergogenic aid for increase sports performance seems to have potential () L-Arginine as a Potential Ergogenic Aidin Healthy Subjects. L-arginine as a potential ergogenic aid in healthy subjects. Sports Medicine, 41(3 ), doi/ Bahra, M., Kapil, V. Dietary nitrates and L-Arginine have been increasingly recognized to play a promising Recently, nitric oxide (NO) has emerged as a promising ergogenic aid by .. factor for exercise tolerance in healthy subjects, suggesting the potential of.

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There is also clearly a need for more studies to verify if L-Arginine enhances strength, power accomplishment and muscular recovery associated with increases in NO production in healthy subjects [ 10 ].

L-Arginine as a potential ergogenic aid in healthy subjects.

Journal of the International Society of Sports Nutrition7 Effects of creatine on exercise healtjy. Effects of creatine supplementation on performance and training adaptations. In summary, it is still premature to recommend dietary supplements containing L-arginine as an ergogenic aid for healthy physically active subjects. Recently, the effect of creatine on protein synthesis in human skeletal muscle has been studied more directly.

L-Arginine as a potential ergogenic aid in healthy subjects.

In order to better understand the magnitude of this heterogeneity, it is worth noting that 7 g of L-Arginine before each resistance exercise bout seems not to influence strength performance, as well as muscle blood volume and oxygenation, while 10 g of L-Arginine seem to proportionate measurable benefits.

Therefore, it still seems premature recommending nutritional supplements containing L-Arginine as an ergogenic aid to increase muscle strength during resistance training [ 24 ].

Oral creatine supplementation in male collegiate athletes: Potential ergogenic effects of l-arginine fall into 2 general categories: Finally, despite the fact that creatine is normally found in cardiac muscle, brain, and testes, these areas remain essentially unstudied with respect to oral creatine supplementation.


Thus, the depletion of PCr and associated reduction in the ability to produce force is delayed, especially in fast muscle fibers. Effect of creatine and weight training on muscle creatine and performance in vegetarians. Arginine is the most abundant carrier of protein nitrogen in animals and, particularly extracellular Arginine, not intracellular, is the main determinant of NO production in endothelial cells [ 1934 ].

Appendix, Table 2 summarizes each study and Table 3 provides an overall summary of the findings. There were only five acute studies retrieved from the literature that evaluated exercise performance after L-arginine supplementation, three of which reported significant improvements. Therefore, nutritional supplements based on L-Arginine should not be recommended to induce hormonal changes and improve exercise performance in trained runners [ 55 ].

One possibility is via stimulation of NO synthesis. Thus, under normal conditions arginine ingestion is not necessary for the stimulation of muscle protein synthesis by ingestion of EAAs. NO increases muscle blood flow, and this has been proposed to be a mechanism responsible for stimulation of muscle protein synthesis under certain conditions, such as during infusion of insulin-like growth factor 1 IGF1 Interestingly, repetitive exercise over weeks, with large muscle mass activation, results in a systemic response in endothelial NO activity [ 8 ].

Typically this amounts to about 1—2 kg in 4—7 d 7577 Arginine as a secretagogue.

Essential amino acids and muscle protein recovery from resistance exercise. Age decreases nitric oxide synthesis and responsiveness in human platelets and increases formation of monocyte-platelet aggregates.

Inorganic nitrate ingestion improves vascular compliance but does not alter flow-mediated ergogeni in healthy volunteers. This seems to be caused by an insulin effect on the uptake 50 Thus, the major advantage of creatine may derive from improved training capacity.

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Nitric Oxide/Arginine: Is Cardiovascular Modulation Effects in Athletes Supplementation?

There seems to be a role for NO in hepatic gluconeogenesis regulation, once high levels of NO are expected to increase the release of glucose from liver under conditions of inducible NO synthase iNOS induction [ 20 ]. PCr serves a major role in energy metabolism. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression.

Effect of creatine loading on endurance capacity and sprint power in cyclists. The results are shown in Table 1. Bioavailability submects NO is known to be reduced in obese subjects, due to reduced synthesis and increased oxidation [ 41 ].

Arginine-based supplements work la-rginine some cases, but have several recurring limitations that question the validity of their conclusions. Arginine has been shown to improve performance-related outcome variables. The effects of a week jump rope exercise program on abdominal adiposity, vasoactive substances, inflammation, and vascular function in adolescent girls with prehypertension.

The mixed supplementation casts doubt on the validity of these conclusions. Creatine, arginine alpha-ketoglutarate, amino acids, and medium-chain triglycerides and endurance and performance.

There are now many different types of NO-producing supplements, split into three major categories: A single dose of beetroot juice enhances cycling performance in simulated altitude. This is avoided because NO is stored in the body as its more stable forms: Effect of dietary supplements on lean mass and strength gains with resistance exercise: