Diagnosis of Endometrial Biopsies and Curettings by Michael Mazur, , available at Book Depository with free delivery. Diagnosis of Endometrial Biopsies and Curettings: A Practical Approach. Veli Marjoniemi. x. Veli Marjoniemi. Search for articles by this author. Department of. Generally, this should comprise a formal curetting rather than an outpatient biopsy. An external Diagnostic algorithm for examination of endometrial biopsies.

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Int J Gynecol Pathol 18 — Mixed epithelial and mesenchymal tumours. Royal Society curettinbs Medicine Press Ltd, Product details Format Hardback pages Dimensions x x In most cases, this is curative, unless the sarcomatous component is high grade or there is sarcomatous overgrowth or myometrial infiltration.

My approach to the interpretation of endometrial biopsies and curettings

These are benign proliferations, and in this situation the presence of architectural complexity does not signify a hyperplastic process. A critical appraisal of the value of immunohistochemistry in the diagnosis of ovarian neoplasms. If intact tissue, comprising glands and stroma, is present then this can be typed, although with a comment that only a limited amount of tissue is available for examination.

Diagnosis of Endometrial Biopsies and Curettings: Briefly, five criteria must be fulfilled for a diagnosis of EIN:. In practice, atypia usually occurs in endometria with complex architecture and it is uncommon to diagnose simple atypical hyperplasia, although this rarely occurs.

My approach to the interpretation of endometrial biopsies and curettings

Some of these may be misinterpreted as endometrial hyperplasia or even as carcinoma if not appreciated to be artefactual. Don’t already have an Oxford Academic account? Polyps are a common cause of abnormal bleeding in premenopausal and postmenopausal women.


Am J Surg Pathol 23 — We use cookies to give you the best possible experience. Considering the classification of endometrial hyperplasia.

Diagnosis of Endometrial Biopsies and Curettings : Michael Mazur :

Some hormone preparations, especially those that contain both oestrogen and progestogen most modern hormone replacement treatment regimenscharacteristically result in a weak or poorly developed secretory endometrium, 2728 whereas with other preparations the endometrium is atrophic. The increasing use of pipelle and other methods of biopsy not necessitating general anaesthesia has resulted in greater numbers of specimens with scant tissue, resulting in problems in assessing adequacy and in interpreting artefactual changes, some of which appear more common with outpatient biopsies.

A further point of confusion is that not all areas of the endometrium respond at the same rate to endogenous or exogenous hormones—for example, some areas may show proliferative features but others exhibit early secretory activity. Int J Gynecol Pathol 23 — In general, secretory activity is rare in endometrial hyperplasias, although this does occur, especially when hormone treatment has already been instigated.

Suggested alternative terminology for classification of precursor lesions of endometrioid adenocarcinoma EIN terminology has been anv championed by Mutter and coworkers. Carcinosarcomas malignant epithelial and mesenchymal components will not be discussed, as these have been recently reviewed. Mullerian adenosarcoma of the uterine corpus associated with tamoxifen therapy: Histopathology 45 — Endometrial samples from women taking tamoxifen tend to be scanty, as tamoxifen may result in fibrosis of the endometrial stroma, making evaluation by biopsy difficult.


Topics such as endometritis, endometrial polyps, changes that are induced by hormones and tamoxifen within the endometrium, endometrial metaplasias and hyperplasias, atypical curettnigs adenomyoma, adenofibroma, adenosarcoma, histological types of endometrial carcinoma and grading of endometrial carcinomas are discussed with regard to endometrial biopsy specimens rather than hysterectomy specimens.

The gynaecologist may believe that a polyp is present, but histological examination shows a cyclical endometrium, often secretory in type, reflecting riagnosis fact that an abundant secretory endometrium may have a polypoid appearance.

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Methods of Endometrial Evaluation. This pseudodecidualisation is often most prominent just beneath the surface glands and is usually accompanied by an inflammatory cell infiltrate, largely comprising natural killer cells. Am J Surg Pathol 8 — This may result in consideration of a wide range of papillary lesions, benign and malignant, which occur in the endometrium.

EIN terminology has been extensively championed by Mutter and coworkers. Serous carcinoma in endometrial polyps.

In these circumstances, successful pregnancies have ensued, although there is a high risk of subsequent recurrence of hyperplasia or carcinoma.

Conversely, serous carcinomas usually show diffuse nuclear p53 reactivity and are oestrogen receptor negative.